Through the Eyes of Retired Clergy: The Impact of the Covid-19 Pandemic and the Future for the Church of England

Data from the Coronavirus, Church & You Survey indicated that retired clergy were feeling less comfortable with the Church's responses to the Covid-19 pandemic and more disaffected from the institutional Church. The subsequent project, Through the eyes of retired clergy, listened in greater depth to how retired clergy felt about the ways in which the Church had responded to the pandemic and to how they saw the future for the Church. In terms of the Church's response to the pandemic, retired clergy were not only realistic and affirming, but also engaged and critical. In terms of the future for the church, retired clergy were realistic and pessimistic. The general view was that the pandemic had accelerated the effect of trends evident before the pandemic. Some would argue that, while the pandemic could have reinforced the visibility of the Church in the local community, such opportunities were largely missed. © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Retinal and optic nerve relapse in retinoblastoma secondary to epiretinal and epipapillary vitreous seeds implantation documented by optical coherence tomography.

BACKGROUND: Retinal retinoblastoma growth phenotypes can be endophytic, exophytic, diffuse infiltrating or anterior diffuse. Herein, we describe a novel tumor growth pattern in two patients. MATERIAL AND METHODS: Imaging with spectral-domain optical coherence tomography (SD-OCT). RESULTS: Both cases were diagnosed with unilateral group D retinoblastoma treated with first-line or bridge intra-arterial chemotherapy (IAC). Case 1 had a new intravitreal/epiretinal relapse 3 months after brachytherapy and intravitreal chemotherapy. SD-OCT showed a disruption of the inner limiting membrane (INL) underneath a parapapillary epiretinal seed. The intravitreal/epiretinal disease completely regressed with intravitreal melphalan. Three months later, an isolated intraretinal growth was documented on SD-OCT at the site of previously INL disruption, which was treated by thermotherapy. He remained disease-free at 1-year follow-up with 0.6 visual acuity. Case 2 was seen 2 months after treatment interruption due to the COVID-19 pandemic. Fundus examination showed a massive intravitreal/epipapillary invasion completely obscuring the papilla. Salvage treatment of this seeing eye consisted of combined intra-arterial and intravitreal melphalan and topotecan injections. An infraclinical papillary regrowth 4 months later was treated with additional IAC. Six months later, enucleation was performed due to an infraclinical papillary relapse with suspicion of intralaminar invasion. Histopathology showed retrolaminar optic nerve invasion with tumor-free surgical section. The child received four cycles of adjuvant chemotherapy and remained disease-free at 1-year follow-up. CONCLUSION: Epiretinal/epipapillary vitreous seeding can be the source of a secondary intraretinal/optic nerve head relapse. SD-OCT is instrumental to follow such cases. Enucleation remains the safest option if secondary optic nerve invasion is suspected.

Timing and Trends for Municipal Wastewater, Lab-Confirmed Case, and Syndromic Case Surveillance of COVID-19 in Raleigh, North Carolina.

Objectives. To compare 4 COVID-19 surveillance metrics in a major metropolitan area. Methods. We analyzed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in wastewater influent and primary solids in Raleigh, North Carolina, from April 10 through December 13, 2020. We compared wastewater results with lab-confirmed COVID-19 cases and syndromic COVID-like illness (CLI) cases to answer 3 questions: (1) Did they correlate? (2) What was the temporal alignment of the different surveillance systems? (3) Did periods of significant change (i.e., trends) align? Results. In the Raleigh sewershed, wastewater influent, wastewater primary solids, lab-confirmed cases, and CLI were strongly or moderately correlated. Trends in lab-confirmed cases and wastewater influent were observed earlier, followed by CLI and, lastly, wastewater primary solids. All 4 metrics showed sustained increases in COVID-19 in June, July, and November 2020 and sustained decreases in August and September 2020. Conclusions. In a major metropolitan area in 2020, the timing of and trends in municipal wastewater, lab-confirmed case, and syndromic case surveillance of COVID-19 were in general agreement. Public Health Implications. Our results provide evidence for investment in SARS-CoV-2 wastewater and CLI surveillance to complement information provided through lab-confirmed cases. (Am J Public Health. Published online ahead of print November 10, 2022:e1-e11. https://doi.org/10.2105/AJPH.2022.307108).

God is in His Heaven, All's Right With the World: Psychological Well-being and Belief in Divine Control During the Third COVID-19 Lockdown Among Anglican Clergy and Laity in England

Drawing on data provided by 1,841 lay or ordained members of the Anglican Church residing in England during the first half of 2021, this study explores the connection between self-perceived change in psychological well-being during the pandemic and belief in divine control over the pandemic. Change in psychological well-being was assessed by The Index of Balanced Affect Change (TIBACh) that distinguishes between positive affect and negative affect, and divine control was assessed by the God in Control of the Pandemic Scale (GiCoPS). After controlling for personal factors (age and sex), psychological factors (psychological type and emotional volatility), contextual factors (education level and ordination status), and ecclesial factors (conservative doctrine and charismatic influence), the data demonstrated a positive association between belief in divine control and change in positive affect, but no association between belief in divine control and change in negative affect.

Anglican cathedrals and implicit religion: Softening the boundaries of sacred space through innovative events and installations

High profile (and controversial) events and installations, like the Helter-Skelter in Norwich and the Crazy Golf Bridges in Rochester, have drawn attention to innovation and public engagement within Anglican cathedrals. The present study contextualised these innovations both empirically and conceptually. The empirical framework draws on cathedral websites to chronicle the wide and diverse range of events and installations hosted by Anglican cathedrals in England and the Isle of Man between 2018 and 2022. The conceptual framework draws on Edward Bailey’s theory of implicit religion to classify and to explore these events and installations. Two insights from the theory of implicit religion emerged as of particular significance. First, the notion of implicit religion softens the boundaries between the sacred and the secular. This was exemplified by eight categories of events: scientific exhibitions, festivals, musical events, art exhibitions, theatre, markets, community events and installations. Second, the notion of implicit religion draws attention to the themes and activities that generate meaning and purpose. This was exemplified by seven themes: social justice and social conscience, violence and reconciliation, remembrance, migration and sanctuary, COVID-19 and lockdowns, personal well-being and nature and environment. Contribution: Situated within the science of cathedral studies, this article identifies the range of innovative events and installations hosted by Anglican Cathedrals in England and the Isle of Man and assesses the significance of these events and installations through Edward Bailey’s lens of implicit religion, discussing first the softening of boundaries between the sacred and the secular and then the generation of meaning and purpose through the core themes raised by these events and installations. © 2022. The Authors.

Lockdown worship in the Church of England: predicting affect responses to leading or accessing online and in-church services

This study draws on data provided to the Covid-19 & Church-21 Survey by 2,017 Anglicans (clergy and laity) living in England to explore the experiences of those leading and those accessing online (pre-recorded and live-streamed) and in-church services within the Church of England between January and July 2021. The data demonstrated that for both those leading services and those accessing services, online worship was less rewarding than in-church worship, even as expressed within the context of Covid restrictions. Moreover, pre-recorded online services were less rewarding than live-streamed services both for those leading and for those accessing services. Among leaders, the return to in-church services was most rewarding for older leaders, lay ministers, Anglo-Catholics, those working in rural churches, extraverts and the emotionally stable.

MALDI(+) FT-ICR Mass Spectrometry (MS) Combined with Machine Learning toward Saliva-Based Diagnostic Screening for COVID-19.

Rapid identification of existing respiratory viruses in biological samples is of utmost importance in strategies to combat pandemics. Inputting MALDI FT-ICR MS (matrix-assisted laser desorption/ionization Fourier-transform ion cyclotron resonance mass spectrometry) data output into machine learning algorithms could hold promise in classifying positive samples for SARS-CoV-2. This study aimed to develop a fast and effective methodology to perform saliva-based screening of patients with suspected COVID-19, using the MALDI FT-ICR MS technique with a support vector machine (SVM). In the method optimization, the best sample preparation was obtained with the digestion of saliva in 10 µL of trypsin for 2 h and the MALDI analysis, which presented a satisfactory resolution for the analysis with 1 M. SVM models were created with data from the analysis of 97 samples that were designated as SARS-CoV-2 positives versus 52 negatives, confirmed by RT-PCR tests. SVM1 and SVM2 models showed the best results. The calibration group obtained 100% accuracy, and the test group 95.6% (SVM1) and 86.7% (SVM2). SVM1 selected 780 variables and has a false negative rate (FNR) of 0%, while SVM2 selected only two variables with a FNR of 3%. The proposed methodology suggests a promising tool to aid screening for COVID-19.

Multifaceted Assessment of Wastewater-Based Epidemiology for SARS-CoV-2 in Selected Urban Communities in Davao City, Philippines: A Pilot Study.

Over 60 countries have integrated wastewater-based epidemiology (WBE) in their COVID-19 surveillance programs, focusing on wastewater treatment plants (WWTP). In this paper, we piloted the assessment of SARS-CoV-2 WBE as a complementary public health surveillance method in susceptible communities in a highly urbanized city without WWTP in the Philippines by exploring the extraction and detection methods, evaluating the contribution of physico-chemical-anthropogenic factors, and attempting whole-genome sequencing (WGS). Weekly wastewater samples were collected from sewer pipes or creeks in six communities with moderate-to-high risk of COVID-19 transmission, as categorized by the City Government of Davao from November to December 2020. Physico-chemical properties of the wastewater and anthropogenic conditions of the sites were noted. Samples were concentrated using a PEG-NaCl precipitation method and analyzed by RT-PCR to detect the SARS-CoV-2 N, RdRP, and E genes. A subset of nine samples were subjected to WGS using the Minion sequencing platform. SARS-CoV-2 RNA was detected in twenty-two samples (91.7%) regardless of the presence of new cases. Cycle threshold values correlated with RNA concentration and attack rate. The lack of a sewershed map in the sampled areas highlights the need to integrate this in the WBE planning. A combined analysis of wastewater physico-chemical parameters such as flow rate, surface water temperature, salinity, dissolved oxygen, and total dissolved solids provided insights on the ideal sampling location, time, and method for WBE, and their impact on RNA recovery. The contribution of fecal matter in the wastewater may also be assessed through the coliform count and in the context of anthropogenic conditions in the area. Finally, our attempt on WGS detected single-nucleotide polymorphisms (SNPs) in wastewater which included clinically reported and newly identified mutations in the Philippines. This exploratory report provides a contextualized framework for applying WBE surveillance in low-sanitation areas.

Giving Up on the Church of England in the Time of Pandemic: Individual Differences in Responses of Non-ministering Members to Online Worship and Offline Services

This study draws on data provided to the Covid-19 & Church-21 Survey by 826 'non-ministering' Anglicans living in England in order to explore why some people gave up worshipping online or in church during the Covid-19 lockdown in 2021. Nearly a quarter of the participants had given up online worship, attending offline services in church, or both: 15 per cent had given up on online worship, 13 per cent had given up on going to church, and 5 per cent had given up on both. Giving up was significantly correlated with negative experience of services. Those under the age of forty and Anglo-Catholics were most likely to give up online worship. Women and extraverts were most likely to give up on socially distanced services in church. The results indicate the sorts of people who might drift from the church post-pandemic and what the Church could concentrate on to prevent this process.

From The Plague Horrors of Cholera, What Partnership Lessons Can Be Learnt in Addressing COVID-19 In Zambia (preprint)

Abstract Since the outbreak of COVID-19 on 31 December 2019, different public health systems have been grappling with how to address the spread of the virus. During the cholera outbreak and the Covid-19 pandemic in Zambia, values such as equity, partnership and collaboration have been recognized as central to resilience and an effective response to the pandemic. In this study we identify lessons that can be used for addressing the COVID-19 pandemic from partnership approach used in confronting the cholera outbreak of 2017-2018 in Zambia Chipata Compound. Method: Data was collected using a qualitative approach; 26 interviews were conducted with Public Health Professionals and community Leaders. Document reviews from government institutions and non-government institutions were also conducted. The Bergen model of Collaborative Functioning was used to guide the analysis of data. Results: A top-down approach was observed to be important in addressing cholera but there was a need to improve a bottom-up approach. Synergistic results, avoidance of duplication, Oral cholera vaccination intervention and collaborative capacity building. Challenges in the partnership collaboration included inadequate resources, poor communication, poor coordination, lack of clear shared vision, reactive response, poor involvement of the community, hegemonic powers and mistrust and resentment Conclusion: From the experience of cholera outbreaks, partnerships are vital in addressing pandemics. Based on the lessons from the cholera outbreaks, we note that there is a need to improve collaboration in partnership if COVID-19 and cholera are to be effectively addressed.

Consumption, nicotine dependence and motivation for smoke cessation during early stages of COVID-19 pandemic in Brazil: A cross-sectional study.

INTRODUCTION: The COVID-19 pandemic may have changed smoking habits. For the smoking population, information regarding smoking habits and the pandemic could potentially aid COVID-19 prevention and control measures. Our study aimed to analyze the effects of the COVID-19 pandemic on tobacco consumption, nicotine dependence levels, and motivation for smoking cessation. We also collected information from smokers regarding their awareness of the consequences of tobacco use and the increased risks smokers have for severe complications from COVID-19. METHODS: In the survey for this observational cross-sectional study, 122 smokers responded to an online form. The participants provided general data about their smoking history, their smoking habits in the months of April and May 2020, and the effect of the pandemic on their smoking habits. They also completed a Fagerström test and were measured by the Wisconsin Smoking Withdrawal Scale. RESULTS: When compared to pre-pandemic levels, the majority of smokers reported increased tobacco consumption of between 1 and 10 cigarettes per day (37.7%). Their motivation to quit smoking (59.8%) and desire to smoke (53.2%) were unchanged by the pandemic. Most participants demonstrated an awareness of the increased risks smokers have for severe COVID-19-related complications (p<0.001). We identified the following correlations: cigarettes/day before pandemic and motivation for smoking cessation (r=0.19; p=0.030), cigarettes/day and nicotine dependence level (r=0.61; p<0.001), and load consumption and nicotine dependence level (r=0.69; p<0.001). No significant correlations were observed between load consumption and motivation to quit (r=0.13; p=0.120). CONCLUSIONS: Most smokers are well aware of their increased risks for severe COVID-19-related complications. In the early stages of the COVID-19 pandemic in Brazil, most smokers reported increased cigarette consumption. In addition, motivation to quit and desire to smoke were unchanged for the majority of smokers.

Spiritual Awakening among Church Members during the Pandemic: An Empirical Study in England and Wales

For some church members the pandemic may have been a challenge to faith, while for others the pandemic may have been an opportunity to re-kindle faith and to trigger spiritual awakening. A sample of 3,673 churchgoers (Anglican and Catholic) completed an online survey during the early months of the lockdown including the Lewis Index of Spiritual Awakening (LISA). The data demonstrated that more participants experienced a sense of spiritual awakening than a spiritual decline. Spiritual awakening was associated with personal factors (being female and older), with psychological factors (feeling types, intuitive types, and emotional stability), with religious identity (being Catholic), with theological tradition (being charismatic and conservative), and with active engagement in online services (lighting candles or typing in prayer requests). Experiencing spiritual awakening during the early months of the lockdown is, thus, associated with religious, theological, and spiritual practices, as well as with personal and psychological factors. © Koninklijke Brill NV, Leiden, 2022

POSA279 The Impact of the COVID-19 Pandemic on the MHRA's Early Access to Medicines Scheme

Objectives: To descriptively analyse public assessment reports (PAR) published by the MHRA through their early access to medicines scheme (EAMS) to establish any trends in product characteristics granted a positive scientific opinion (SO), the impact of an SO on subsequent technology assessment (TA) by the National Institute for Health and Care Excellence (NICE), and the impact of the COVID-19 pandemic on the EAMS process. Methods: All available PARs and NICE TA documents were obtained from their respective websites, and data relating to drug, indication, justifications for positive SO, and NICE recommendation details extracted. Results: Of the 41 available PARs published between July 2015 and June 2021, oncology and genetic disorders were the most assessed indications with 24 (58.5%), and 9 (22%) related PARs respectively. The most frequent drug class were monoclonal antibodies, featuring in n=19 (46%) PARs. Of those granted an SO, n=28 underwent a NICE TA resulting in n=26 approvals, of which n=4 were recommended for use only within the cancer drugs fund. Of the recommended therapies, 20 (77%) had a commercial agreement such as a simple discount patient access scheme, in place. During the COVID-19 pandemic (April 2020-April 2021), 11 drugs were granted a positive SO versus 5 drugs in the previous 12 months. Monoclonal antibodies were the most common drug class in both time periods, with 3 (27%) and 2 (40%) granted an SO between April 2019-2020, and April 2020-2021 respectively. Conclusions: High rates of NICE TA approval (>90%) were observed in products granted an positive SO through EAMS however, most were subject to a commercial agreement, suggesting that engaging with the EAMS scheme doesn’t lead to preferential pricing. The COVID-19 pandemic appears to have had no impact on the EAMS scheme, with an increase noted in the number of positive SOs granted during the pandemic versus the previous year.

Noninvasive Diagnostic for COVID-19 from Saliva Biofluid via FTIR Spectroscopy and Multivariate Analysis.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the worst global health crisis in living memory. The reverse transcription polymerase chain reaction (RT-qPCR) is considered the gold standard diagnostic method, but it exhibits limitations in the face of enormous demands. We evaluated a mid-infrared (MIR) data set of 237 saliva samples obtained from symptomatic patients (138 COVID-19 infections diagnosed via RT-qPCR). MIR spectra were evaluated via unsupervised random forest (URF) and classification models. Linear discriminant analysis (LDA) was applied following the genetic algorithm (GA-LDA), successive projection algorithm (SPA-LDA), partial least squares (PLS-DA), and a combination of dimension reduction and variable selection methods by particle swarm optimization (PSO-PLS-DA). Additionally, a consensus class was used. URF models can identify structures even in highly complex data. Individual models performed well, but the consensus class improved the validation performance to 85% accuracy, 93% sensitivity, 83% specificity, and a Matthew's correlation coefficient value of 0.69, with information at different spectral regions. Therefore, through this unsupervised and supervised framework methodology, it is possible to better highlight the spectral regions associated with positive samples, including lipid (∼1700 cm-1), protein (∼1400 cm-1), and nucleic acid (∼1200-950 cm-1) regions. This methodology presents an important tool for a fast, noninvasive diagnostic technique, reducing costs and allowing for risk reduction strategies.

Churches and Faith: Attitude Towards Church Buildings During the 2020 COVID-19 Lockdown Among Churchgoers in England

Attitude toward church buildings was assessed among a sample of 6,476 churchgoers in England during the first COVID-19 pandemic lockdown in 2020. The six-item Scale of Attitude toward Church Buildings (SACB) assessed a range of aspects of attitude that included the importance of buildings for Christian faith generally, and buildings as central to the expression of Christian faith. Anglo-Catholics and Roman Catholics showed similar positive attitude towards buildings, Anglican Evangelicals showed a less positive attitude on average that was similar to those from Free-Churches, while Broad-Church Anglican attitude lay between these two extremes. Younger people had a more positive attitude than older people, especially among Catholics. On average, men had more a positive attitude than women, and lay people a more positive attitude than clergy. These findings suggest that the significance of buildings varies among traditions in ways that may still reflect historical issues of the Reformation. © Koninklijke Brill NV, Leiden, 2021

Shaping attitudes toward church in a time of coronavirus: Exploring the effects of personal, psychological, social, and theological factors among church of England clergy and laity

This paper reports on the effect of personal, psychological, social, and theological factors in shaping attitudes toward church buildings, the lockup of churches, and the trajectory into virtual church among 4,374 clergy and lay people from the Church of England during the first UK COVID-19 lockdown in 2020. Data from an online survey were used to create three scales, Pro Church Buildings, Anti Church Lockup, and Pro Virtual Church, which were shown to have adequate internal consistency reliability. Five sets of predictor variables were tested using hierarchical multiple regression: personal factors (sex and age), psychological factors (psychological type scores), social location (ordination status, education, geographic location), theological stance (modern versus traditional worship, liberal versus conservative doctrinal belief, liberal versus conservative views on morality), and Church tradition (Anglo-Catholic, Broad Church, Evangelical, and Charismaticism). The three scales were predicted by slightly different sets of variables, but in each case personal factors and psychological factors retained some predictive power after controlling for other sorts of factors. The results suggest that those most likely to embrace a future with a significant role for church life online are women (rather than men), the middle-aged (rather than younger or older people), intuitive (rather than sensing) and feeling (rather than thinking) psychological types, clergy (rather than laity), those living outside the inner cities, those who prefer modern (rather than traditional) forms of worship, those with more liberal (rather than conservative) views on doctrine and morality, and those who embrace Evangelical and Charismatic (rather than Anglo-Catholic) church traditions. © Koninklijke Brill NV, Leiden, 2021.